Genetic details on RYR1 variants

Identified a variant in RYR1? Want to know the effect on translation? Grantham score? REVEL score? Just visit https://www.emhg.org/genetics go to ‘TEST SNV’ and have a look.

Remembering Ron Litman

We were greatly saddened to learn that Ron Litman, Professor of Anesthesiology and Pediatrics, Perelman School of Medicine at the University of Pennsylvania and Anesthesiologist at The Children's Hospital of Philadelphia, Philadelphia, PA recently passed away. Ron was a paediatric anaesthetist by heart and a driving force for improved safety in anaesthesia, with a major interest in MH. He was heavily involved in MHAUS and he engaged constructively with the EMHG on numerous occasions. We have known Ron for many years and appreciated him as an open minded, extremely knowledgeable and loyal colleague. He will be greatly missed.

2021 EMHG annual meeting goes digital!

The 2021 annual meeting will be a digital experience. Please see details

Meeting dates are 13.5.2021 - 15.5.2021. Registration is 150€.

we are looking forward to ‘see’ each other!

MHApp is back....

I’d like to inform you, that after years (literally!) of re-programming the MHApp is finally back in the AppStore.
The app is a complete re-write and presents in a refreshed user interface.

https://apps.apple.com/app/mhapp-malignant-hyperthermia/id392766134

Please report any inconsistencies, problems, errors etc. to me!

As the income from the paid app was very low (a couple of hundred dollars per year) and never even closely compensated for the workload, I have decided to have it as a free app.

hope you like it!

ps: it is currently only in English. German will follow very soon.

Free EMHG membership

The EMHG offers free membership until May 2021. If you are interested, you can sign up here

Perioperative management of malignant hyperthermia suspected or susceptible patients

The EMHG has published guidelines on the perioperative management of malignant hyperthermia suspected or susceptible patients

https://doi.org/10.1016/j.bja.2020.09.029

in memoriam of Neil Eastwood Steet

We have the sad duty to inform you, that Dr Neil Eastwood Street has passed away. His memories will last in our group, please read the obituary.

Stocking of dantrolene: guidelines published

The EMHG has published guidelines on the availability (stocking) of dantrolene.

COVID-19 and EMHG Meeting 2020, Nijmegen

The local organising committee and EMHG Executive Committee recognise that uncertainty surrounding the potential consequences of COVID-19 includes the potential for restrictions on travel, meetings and leave from hospital duties. Currently, there are no reasons to think that Nijmegen might be a high-risk location for COVID-19 but should the situation change we will be guided by the authorities in the Netherlands. We would like to encourage those who have registered, or wish to register, to pay their registration fee as soon as possible. The EMHG guarantees full reimbursement of the registration fee if the meeting is cancelled or you receive advice (from your government or employer) that you should not travel.

If you are making travel arrangements we would suggest that you ensure you have travel insurance that will recover these costs should the meeting be cancelled or you are prevented from travelling by the COVID-19 situation. If you are unable to obtain such insurance, we would suggest you do not book your travel until the beginning of April when we hope the situation will be clearer.

Register for the 2020 annual meeting

use the following link to register for the 2020 annual meeting: https://www.emhg-2020.com

Partnership award for 2020 annual meeting

This is to emphasize the availability of the EMHG partnership award. Please consult the information on the website.

Relocation of head office of the EMHG

According to the constitution of the group, the board of directors were consulted for a relocation of the head office. This has been approved and the head office has been relocated to Lund, Sweden.

Genetics: European molecular quality network (EMQN)

The European molecular quality network (EMQN) are excited to announce that RYR1 External Quality Assessment (EQA) scheme introduced in 2019 for laboratories performing analysis of variants in the RYR1 gene for related myopathies and malignant hyperthermia susceptibility is also available in 2020.

Although the deadline is already officially closed, late registrations are possible by contacting the EMQN office directly (office@emqn.org).

The RYR1 EQA scheme is designed to test the whole analytical process. Three DNA samples will be distributed to participating laboratories in January 2020 for genetic analysis with case scenarios, the samples are suitable for sequencing and copy number analysis. Clinical reports from the participating laboratories will be evaluated for three elements; genotyping, interpretation, and clerical accuracy by a panel of expert peer assessors.

Please see the EMQN website (https://www.emqn.org) or contact office@emqn.org for further information.

The EMHG executive committee at work!

Scoring matrix for classification of pathogenicity of genetic variants in MH susceptibility

The EMHG has consented on a modification of the ACMG criteria in order to establish a scoring matrix for classification of pathogenicity of genetic variants in malignant hyperthermia susceptibility.

Honorary membership for Diana Bendixen

The EMHG is proud to announce honorary membership for Diana Klitgaard Bendixen

Prizes at the 2019 annual meeting

The EMHG is proud to announce the following prize winners at the 2019 annual meeting in Potsdam

Best basic research presentation

Vikas Kaura from Leeds, UK

“Enhanced Sarcolemmal CalciumInflux in Malignant HyperthermiaSusceptible Mice and Humans”

Best clinical presentation

Sebastian Heiderich from Hannover, Germany

“Trigger-free long duration minimalflow ventilation using activated charcoal filters"

Presentation award from the public

Paul D. Allen from Leeds UK

“Clinical MH can be prevented with non-depolarizing neuromuscular blockers”